Testosterone Use Linked to Higher Risk of Central Serous Retinopathy

A new study found that taking testosterone—whether by patch, injection, or supplement—may increase the risk of developing central serous chorioretinopathy (CSCR), a condition where fluid leaks under the retina and causes blurry or distorted vision.

Researchers reviewed large medical databases and discovered that patients on testosterone therapy had higher average testosterone levels and blood counts, and were more likely to develop CSCR compared to non-users. Although some results weren’t statistically strong due to smaller sample sizes, the overall link remained significant.

Scientists believe testosterone may raise pressure in the tiny blood vessels behind the eye or make them more “leaky,” allowing fluid to collect under the retina. Another possible cause is overstimulation of the body’s stress-response system, which can damage the retinal cells that normally keep fluid out.

The study’s authors advise doctors to ask about testosterone use when diagnosing CSCR and to educate patients on the potential risk. Since testosterone therapy is a modifiable factor, adjusting or stopping it may help prevent recurrence or long-term vision damage.