"In a study comparing Lacrisert once daily with artificial tears used at least 4 times a day, Lacrisert was more effective at relieving symptoms and was able to help existing tears stay longer on the eye surface. Most patients in clinical studies preferred lacrisert over artificial tears."
"O.D.s should counsel families about risk factors (high accommodative lag/ esophoria at near, low amounts of myopia, two myopic parents) and suggest that PALs may be useful to slow the progression of myopia and prevent the development of high myopia when a child has one or more of these risk factors. For children who do not fall into these categories, PALs do not appear to offer any clinical advantage to slow the progression of myopia vs. SVLs."
In children with these risk factors, myopia progressed between .50 D and .68 D less in three years than the controls when they wore the PALS.
This report explains the importance of lighting conditions while doing gonioscopy. Oftentimes the light is bright enough so that the pupil constricts and widens the angle, creating the impression that a closed angle is actually open.
"Patients with obstructive sleep apnea demonstrated significant 24-hour IOP fluctuations (3 mmHg more), with the highest values at night. CPAP therapy causes an additional IOP increase, especially at night. Regular screening of visual fields and the optic disc is warranted for all patients with OSA, especially those treated with CPAP.
"Hearing thresholds at frequencies that are important for speech comprehension are significantly worse in individuals with ocular pseudoexfoliation than in matched controls. This finding may support the multiorgan nature of pseudoexfoliation syndrome."
"At least with respect to the brand of lenses tested, the fitting of aspheric design soft contact lenses does not result in superior visual acuity, aberration control, or subjective appreciation compared with equivalent spherical design soft contact lenses."
Keep in mind that we may still get corneal ulcers with silicone hydrogel lenses, even on a daily wear schedule. I'm interested to see studies done with Purevision and Night and Day contact lenses, and with 30 day continuous vs. daily wear.
"Increased oxygen permeability associated with silicone hydrogel contact lenses may reduce, but does not eliminate, the risk of pseudomonas keratitis. Studies have yet to quantify the risk of keratitis associated with daily wear of these lens materials. Further study is necessary to identify the risks of complications with daily wear of silicone hydrogel lenses and to determine which factors may contribute to those risks."
"Methotrexate seems to be a well-tolerated therapy that can reduce inflammation successfully and can decrease the corticosteroid requirement in the treatment of chronic, noninfectious, and nonnecrotizing scleritis."
"In this black population, cardiovascular mortality tended to increase in persons with previously diagnosed/treated OAG and ocular hypertension. The excess mortality associated with timolol maleate treatment of OAG, also found in a white population, warrants further investigation."
This report suggests that deficiency in Vitamin B12 and folate can increase risk of CRVO due to elevated homocysteine levels. It concludes:
"Vitamin B12 and folate deficiency can lead to elevated levels of homocysteine. We found a large amount of published data relating central retinal vein occlusion to elevated homocysteine levels, but there was a lack of conclusive evidence for this association Patients should be asked about their dietary history where a thrombotic event is suspected or confirmed."
"Mild to moderate elevation of homocysteine may explain the role of vascular dysregulation and endothelial dysfunction in patients with diabetic retinopathy. Hyperhomocysteinemia may be one of the crucial risk factors for development of macular edema"