Melatonin Provides Anxiolysis, Enhances Analgesia, Decreases Intraocular Pressure, and Promotes Better Operating Conditions During Cataract Surgery Under Topical Anesthesia -- Ismail and Mowafi 108 (4): 1146 -- Anesthesia & Analgesia
A 10mg tablet of Melatonin significantly reduced the anxiety scores. Perioperative verbal pain scores were significantly lower in the melatonin group with less intraoperative fentanyl requirement. Melatonin also decreased IOP (mean ± sd) significantly from 17.9 ± 0.9 to 14.2 ± 1.0 mm Hg after premedication
CONCLUSION: We concluded that oral melatonin premedication for patients undergoing cataract surgery under topical anesthesia provided anxiolytic effects, enhanced analgesia, and decreased IOP resulting in good operating conditions.