Drugs Linked to Retinal Detachment

By Dr. Kevin -


 A large study published in Eye analyzed over 17 million FDA adverse event reports to find drugs linked to retinal detachment (RD). Researchers identified 30 medications with significant RD associations, including eye drops, cancer drugs, corticosteroids, and erectile dysfunction medications.

The strongest links were seen with pilocarpine, encorafenib, and ocriplasmin, while drugs like prednisolone, bevacizumab, and topiramate had weaker connections. The time to RD onset varied—anticancer drugs caused it soonest (around two weeks), while erectile dysfunction drugs had the longest delay (about a year).

Younger adults (<65) and men were more prone to RD from certain drug classes, especially ophthalmic agents. Older adults (65+) were more affected by corticosteroids, and women showed higher risk with cefuroxime and encorafenib.

Different drugs were tied to different types of RD: cancer drugs often to exudative, anti-VEGF agents like aflibercept to regmatogenous, and bevacizumab to tractional.

The authors emphasize that patients taking these medications—especially high-risk ones—should have regular eye exams and be educated to report early RD symptoms like flashes, floaters, or sudden vision changes.

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