A FEW SYSTEMIC DRUGS THAT CAN CAUSE EYE PROBLEMS

By Dr. Kevin -

 A new study in the International Journal of Surgery analyzed data from the FDA Adverse Event Reporting System (2004–2024) to find which systemic (whole-body) drugs are most often linked to eye problems.

The most common eye conditions reported were cataract, dry eye, and glaucoma, with blurred vision and eye pain being the most frequent symptoms. In total, 141 drugs were identified, spanning categories such as cancer treatments, nervous system drugs, infection treatments, immune/inflammatory drugs, cardiovascular and endocrine therapies, and respiratory drugs.

  • Dupilumab (for atopic dermatitis) was the drug most often linked to eye issues. It can damage goblet cells in the conjunctiva, reducing tear production and causing dry eye disease.

  • Belantamab mafodotin (for multiple myeloma) caused frequent blurred vision and dry eye.

  • Fingolimod (for multiple sclerosis) was the next most common, known for causing macular edema.

  • Moxifloxacin (oral form) was linked to uveitis, showing that the way a drug is given can affect its risk profile.

The study emphasizes the importance of early recognition and monitoring of high-risk drugs to prevent medication-related eye damage. It encourages healthcare providers to weigh drug benefits against potential ocular adverse reactions and to monitor vulnerable patients closely.

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