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Nitrates May Help Lower Glaucoma Risk, Study Finds


A recent American Journal of Ophthalmology study reveals a potential protective role of chronic oral nitrate use against open-angle glaucoma (OAG). Analyzing real-world data, researchers found that long-term nitrate use was associated with a significantly lower risk of OAG and primary open-angle glaucoma at three and five years, but had no effect at one year. This suggests nitrates may influence glaucoma pathogenesis beyond IOP reduction.A study in the American Journal of Ophthalmology found that people who regularly take oral nitrates (like nitroglycerin) for heart disease had a lower risk of developing open-angle glaucoma (OAG) after three and five years, though not after just one year. They also needed glaucoma medications less often during that time.

Researchers looked at data from over 30,000 patients with heart disease. Those taking nitrates had slightly lower rates of glaucoma compared to those who didn’t. However, nitrate use didn’t seem to affect the risk of ocular hypertension (OHT), a related condition.

The study suggests nitrates might help protect the optic nerve by improving blood flow and reducing stress on nerve cells. But since it’s an observational study, more research is needed to prove if nitrates actually prevent glaucoma or slow its progress.




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