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Tuesday, April 14, 2015

THYMOSIN β4 FOR SEVERE DRY EYE

Cornea

Statistically significant differences in both symptom and sign assessments, were seen at various time points throughout the study. Of particular note at day 56, the treated group had 35.1% reduction of ocular discomfort compared with vehicle control, and 59.1% reduction of total corneal fluorescein staining compared with vehicle control. Other improvements seen in the RGN-259–treated patients included tear film breakup time and increased tear volume production.
Conclusions: In this small trial, RGN-259 eye drops were safe and well tolerated and met key efficacy objectives with statistically significant symptom and sign improvements, compared with vehicle control, at various time intervals, including 28-days posttreatment.

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