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Tuesday, March 24, 2009

MELATONIN DECREASES ANXIETY, PAIN, AND IOP DURING CATARACT SURGERY

Melatonin Provides Anxiolysis, Enhances Analgesia, Decreases Intraocular Pressure, and Promotes Better Operating Conditions During Cataract Surgery Under Topical Anesthesia -- Ismail and Mowafi 108 (4): 1146 -- Anesthesia & Analgesia

A 10mg tablet of Melatonin significantly reduced the anxiety scores. Perioperative verbal pain scores were significantly lower in the melatonin group with less intraoperative fentanyl requirement. Melatonin also decreased IOP (mean ± sd) significantly from 17.9 ± 0.9 to 14.2 ± 1.0 mm Hg after premedication

CONCLUSION: We concluded that oral melatonin premedication for patients undergoing cataract surgery under topical anesthesia provided anxiolytic effects, enhanced analgesia, and decreased IOP resulting in good operating conditions.

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