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Tuesday, December 16, 2008

NEW TOPICAL STEROID, DUREZOL

Durezol (difluprednate ophthalmic emulsion) 0.05% is a topical ophthalmic steroid that has the potential to treat patients suffering from ocular inflammatory diseases, including post-operative inflammation. Durezol is a difluorinated derivative of prednisolone and has potent anti- inflammatory activity. The efficacy and safety of Durezol in ocular inflammatory diseases has been demonstrated in an extensive preclinical and clinical program in Japan.

One interesting result from the phase III studies is that BID dosing was just as effective as QID dosing. 3% have significant IOP rise.

3 comments:

  1. Anonymous9:03 AM

    It was also proven effective in treating uveitis QID verses Pred Forte eight times a day. See the 10-14-08 press release here http://www.siriontherapeutics.com/investmed/presrel.html

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  2. Anonymous6:44 AM

    What is the effect of this drug on IOP.

    ReplyDelete
  3. From http://www.medicalnewstoday.com/articles/112624.php

    "According to the Phase III study results:
    Three percent of subjects in each of the BID and QID groups, and one percent of subjects in the placebo group met the criterion for a clinically significant rise in IOP, defined as an observed value of greater than or equal to 21 mm Hg and a change from baseline of 10 mm Hg."

    I don't know how this compares with Pred Forte

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