Durezol (difluprednate ophthalmic emulsion) 0.05% is a topical ophthalmic steroid that has the potential to treat patients suffering from ocular inflammatory diseases, including post-operative inflammation. Durezol is a difluorinated derivative of prednisolone and has potent anti- inflammatory activity. The efficacy and safety of Durezol in ocular inflammatory diseases has been demonstrated in an extensive preclinical and clinical program in Japan.
One interesting result from the phase III studies is that BID dosing was just as effective as QID dosing. 3% have significant IOP rise.