SCLERAL CONTACT LENSES AND CORNEA HYPOXIA

According to this study in Optometry and Vision Science:

The purpose of this study is to examine the change in corneal thickness and posterior curvature following 8 hours of miniscleral contact lens wear. Although a small amount of corneal swelling was induced following 8 hours of miniscleral lens wear, modern high Dk miniscleral contact lenses that vault the cornea do not induce clinically significant corneal edema or hypoxic–related posterior corneal curvature changes during short–term wear. Longer–term studies of compromised eyes are still required to inform the optimum lens and fitting characteristics for safe scleral lens wear to minimize corneal hypoxia.

INTRAOCULAR PRESSURE AND EXERCISE

Interesting study in Optometry and Vision Science concluded...

There was a significant IOP-lowering effect, which was persistent for 10 min after 30 min of exercise. The IOP change was dependent on the initial IOP reading and initial heart rate.

CONTACT LENS WEAR AND MEIBOMIAN GLAND DISEASE

According to Ophthalmic and Physiologic Optics:

Alterations to meibomian gland morphology and function accompany contact lens wear. Although these changes onset during the first 2 years of wear, prolonged CL exposure beyond this point does not appear to be associated with further modification. Cessation of wear for at up to 6 months does not lead to resolution.

RETINAL GANGLION CELL THINNING AND ALZHEIMER'S

According to Acta Ophthalmologica,

Ganglion cell layer reduction was associated with ...greater (Alzheimer's) disease severity.